Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Really statistical explanation is a hitherto neglected form of noncausal scientific explanation. Explanations in population biology that appeal to drift are RS explanations. An RS explanation supplies a kind of understanding that a causal explanation of the same result cannot supply. Roughly speaking, an RS explanation shows the result to be mere statistical fallout.

Why should the work of the ancient and the medievals, so far as it relates to nature, still be of interest and an inspiration to us now? The contributions to this enlightening volume explore and uncover contemporary scholarship's debt to the classical and medieval past. Thinking About the Environment synthesizes religious thought and environmental theory to trace a trajectory from Mesopotamian mythology and classical and Hellenistic Greek, through classical Latin writers, to medieval Christian views of the natural world and our (...) relationship with it. The work also offers medieval Arabic and Jewish views on humanity's inseparability from nature. The volume concludes with a study of the breakdown between science and value in contemporary ecological thought. Thinking About the Environment will be a invaluable source book for those seeking to address environmental ethics from a historical perspective. (shrink)

A response to Michael Moxter's account of the need for 'religious feeling' for social order, suggesting that togetherness is currently promoted in overtly non-religious ways, and that true piety may often be at odds with social - and especially with state - order.

In recent years a number of books have been published that offer short autobiographical essays of academics, focusing on their research and how their life history affected their scholarly development. These could be labeled as "intellectual journey narratives." Some volumes focus on philosophers and their religious faith or lack thereof (e.g., Clark, 1997, Antony, 2007). Psychology has its own version of the intellectual journey narrative, in T. S. Krawiec's (1972, 1974, 1978) multivolume set of autobiographical essays by contemporary psychologists. (...) In 1987, Rosemary Pilkington edited her first volume of essays entitled Men and Women of Parapsychology: Personal Reflections, Esprit Volume 1. It contains autobiographical essays by Jule Eisenbud, Montague Ullman, Jan Ehrenwald, Eileen Coly, Joseph H. Rush, Gertrude R. Schmeidler, Emilio Servadio, Renée Haynes, Hans Bender, Karlis Osis, George Zorab and Bernard Grad. The second (2013) volume contains autobiographical essays by Mary Rose Barrington, Eberhard Bauer, William Braud (now deceased), Stephen Braude, Richard S. Broughton, Larry Dossey, Sally Rhine Feather, Erlendur Haraldsson, Arthur Hastings, Stanley Krippner, Lawrence LeShan, Roger Nelson, John Palmer, Guy Leon Playfair, William G. Roll (now deceased), Serena Roney-Dougal, Stephan A. Schwartz, Rex G. Stanford, Russell Targ, Charles T. Tart, and Walter von Lucadou. Between the two volumes almost every significant contemporary parapsychologist is represented, with the major exceptions being the late John Beloff and the late Ian Stevenson. (shrink)

I consider reasons for questioning ‘the laws of logic’, and suggest that these laws do not accord with everyday reality. Either they are rhetorical tools rather than absolute truths, or else Plato and his successors were right to think that they identify a reality distinct from the ordinary world of experience, and also from the ultimate source of reality.

1. Believing Enough to Think The Scottish system of university education requires most aspirants to an Ordinary Degree to study some philosophy. Philosophers in Scottish Universities must therefore contend with enormous first-year classes, stocked with youngsters who have little real desire to be philosophers, or even to philosophize. Some years ago, at Glasgow, a question in the final exam was as follows: ‘“Philosophy is of no use, and so should not be studied.” Discuss’. A couple of hundred students answered, more (...) or less fluently, that one should not assume that what was of no use should not be studied, since some things were worth studying in their own right, but that in any case the study of philosophy was useful since it helped one to question what authoritative figures said. No essayist, apparently, saw any paradox in this reply, which was, of course, taken word for word from the professor's lectures. (shrink)

We support the ambitious goal of unification within the behavioral sciences. We suggest that Darwinian evolution by means of natural selection can provide the integrative glue for this purpose, and we review our own work on selective investment theory (SIT), which is an example of how other-regarding preferences can be accommodated by a gene-centered account of evolution. (Published Online April 27 2007).

For all the time and effort expended on empowerment and participation ‘programmes’, many fail each year. This paper argues that the cause is a faulty view of communication widespread among managers and their teachers: the conduit, transmission model. It frustrates participation and is an ideology of management control. It rests on untenable beliefs about meaning and how language relates to the world. The paper proposes a new model of communication in terms of ‘communicating other/wise’ and offers examples of how it (...) can be practised in management education and by managers aiming to bring empowered and participatory workplaces into being. (shrink)

Most philosophical explorations of responsibility discuss the topic solely in terms of metaphysics and the "free will" problem. By contrast, these essays by leading philosophers view responsibility from a variety of perspectives -- metaphysics, ethics, action theory, and the philosophy of law. After a broad, framing introduction by the volume's editors, the contributors consider such subjects as responsibility as it relates to the "free will" problem; the relation between responsibility and knowledge or ignorance; the relation between causal and moral responsibility; (...) the difference, if any, between responsibility for actions and responsibility for omissions; the metaphysical requirements for making sense of "collective" responsibility; and the relation between moral and legal responsibility. The contributors include such distinguished authors as Alfred R. Mele, John Martin Fischer, George Sher, and Frances Kamm, as well as important rising scholars. Taken together, the essays in _Action, Ethics, and Responsibility_ offer a breadth of perspectives that is unmatched by other treatments of the topic. Contributors: Joseph Keim Campbell, David Chan, Randolph Clarke, E.J. Coffman, John Martin Fischer, Helen Frowe, Todd Jones, Frances Kamm, Antti Kauppinen, Alfred R. Mele, Michael O'Rourke, Paul Russell, Robert F. Schopp, George Sher, Harry S. Silverstein, Saul Smilansky, Donald Smith, Charles T. Wolfe The hardcover edition does not include a dust jacket. (shrink)

This dissertation contends that the inarticulate but implicit philosophical substructure of Twelve-Step Programs is congruent with American Pragmatism developed by Charles Peirce and William James, and that attempts by current Christian writers to assimilate the insights of Twelve-Step Programs fail because they do not take that substructure into account. At its conclusion, it proposes more integral ways of bringing Twelve-Step Program Theory and Christian Theology into conversation. ;Current Christian appropriations tend to proceed by renaming the Higher Power as God, or (...) by renaming addiction as sin. They also, following the paradigm of personal salvation, tend to individualize the understanding of recovery. In doing so, they fail to grasp the constitutive force in Twelve-Step Program Theory of physical addiction, of theological reticence, and of group reflection. In Twelve-Step Programs, these elements necessarily focus the attention of those in recovery on bodily habits and away from metaphysical speculation or rigidity, at the same time that they acknowledge human continuity and fallibility. ;These components, overlooked by Christian popularizations of recovery, are not only integral to Twelve-Step Program Theory, but are also characteristic of American Pragmatism. The second half of the dissertation is a study of William James and Charles Peirce and a demonstration of the intellectual congruence of Twelve-Step Program Theory with their thought. American Pragmatism provides both the interpretive tool and the coherent substructure through which Twelve-Step Program Theory can be seen, first, as intellectually cohesive and, second, as accessible to a deeper participation in theological discussions. ;The conclusion exemplifies and anticipates this more fruitful conversation between Twelve-Step Program Theory and Christian Theology. Those whose theological method has been formed in Twelve-Step Programs will consider their somatic location, their vague and fallible cognition, and their communal rationality to be foundational for their reasoning. These elements will necessarily become critiques of certain areas in traditional theology, at the same time that they will offer certain reconstructions. (shrink)

In this paper, we set out a basic approach to the modeling of narrative in interactive virtual worlds. This approach adopts a bipartite model taken from narrative theory, in which narrative is composed ofstoryanddiscourse. In our approach, story elements — plot and character — are defined in terms of plans that drive the dynamics of a virtual environment. Discourse elements — the narrative’s communicative actions — are defined in terms of discourse plans whose communicative goals include conveying the story world (...) plan’s structure. To ground the model in computational terms, we provide examples from research under way in the Liquid Narrative Group involving the design of the Mimesis system, an architecture for intelligent interactive narrative incorporating concepts from artificial intelligence, narrative theory, cognitive psychology and computational linguistics. (shrink)

In this paper, we set out a basic approach to the modeling of narrative in interactive virtual worlds. This approach adopts a bipartite model taken from narrative theory, in which narrative is composed ofstoryanddiscourse. In our approach, story elements — plot and character — are defined in terms of plans that drive the dynamics of a virtual environment. Discourse elements — the narrative’s communicative actions — are defined in terms of discourse plans whose communicative goals include conveying the story world (...) plan’s structure. To ground the model in computational terms, we provide examples from research under way in the Liquid Narrative Group involving the design of the Mimesis system, an architecture for intelligent interactive narrative incorporating concepts from artificial intelligence, narrative theory, cognitive psychology and computational linguistics. (shrink)

In this paper, we set out a basic approach to the modeling of narrative in interactive virtual worlds. This approach adopts a bipartite model taken from narrative theory, in which narrative is composed of story and discourse. In our approach, story elements — plot and character — are defined in terms of plans that drive the dynamics of a virtual environment. Discourse elements — the narrative’s communicative actions — are defined in terms of discourse plans whose communicative goals include conveying (...) the story world plan’s structure. To ground the model in computational terms, we provide examples from research under way in the Liquid Narrative Group involving the design of the Mimesis system, an architecture for intelligent interactive narrative incorporating concepts from artificial intelligence, narrative theory, cognitive psychology and computational linguistics. (shrink)

Frege famously claimed that logic is the science of truth: “To discover truths is the task of all science; it falls to logic to discern the laws of truth” (Frege, 1956, p. 289). But just like the other foundational concept of set, truth at that time was intimately associated with paradox; in the case of truth, the Liar paradox. The set-theoretical paradoxes had their teeth drawn by being recognised as reductio proofs of assumptions that had seemed too obvious to warrant (...) stating explicitly, but were now seen to be substantive, and more importantly inconsistent. Tarski includes the Liar paradox in his classic discussion of the concept of truth (Tarski, 1956), and developed it, in the form of his famous theorem on the undefinability of truth, as a reductio of the assumption that a language could be semantically closed, in the sense of being able to contain its own truth-predicate.Frege famously claimed that logic is the science of truth: “To discover truths is the task of all science; it falls to logic to discern the laws of truth” (Frege, 1956, p. 289). But just like the other foundational concept of set, truth at that time was intimately associated with paradox; in the case of truth, the Liar paradox. The set-theoretical paradoxes had their teeth drawn by being recognised as reductio proofs of assumptions that had seemed too obvious to warrant stating explicitly, but were now seen to be substantive, and more importantly inconsistent. Tarski includes the Liar paradox in his classic discussion of the concept of truth (Tarski, 1956), and developed it, in the form of his famous theorem on the undefinability of truth, as a reductio of the assumption that a language could be semantically closed, in the sense of being able to contain its own truth-predicate. (shrink)

The volume includes twenty-five research papers presented as gifts to John L. Bell to celebrate his 60th birthday by colleagues, former students, friends and admirers. Like Bell’s own work, the contributions cross boundaries into several inter-related fields. The contributions are new work by highly respected figures, several of whom are among the key figures in their fields. Some examples: in foundations of maths and logic ; analytical philosophy, philosophy of science, philosophy of mathematics and decision theory and foundations of economics. (...) Most articles are contributions to current philosophical debates, but contributions also include some new mathematical results, important historical surveys, and a translation by Wilfrid Hodges of a key work of arabic logic. (shrink)

In order to survive, the developing conceptus must interrupt the normal ovarian cycle of the mother and extend the production of progesterone by the corpus luteum. An unusual Type 1 interferon (IFN), related structurally to the IFN–α molecule and produced in massive amounts for only a few days by the first epithelium (trophectoderm) of the preimplantation conceptus, has been implicated as the antiluteolytic agent in sheep and cattle. IFN‐a therapy during this critical period can also improve pregnancy success in sheep. (...) It remains unclear, however, whether the trophoblast IFN have specialized biological properties or whether they are unique merely in the timing, magnitude and site of their expression. (shrink)

In this article I interpret the conversation that takes place between Socrates and Polemarchus in Book One of the Republic according to its dramatic logic by examining the rhetorical artfulness that informs Socrates’ argumentative tactics. After first examining Polemarchus’s character as obedient spiritedness, I then turn to the argument, showing that Socrates does not undermine Polemarchus’s original opinion but, rather, by making legitimate use of the analogy between justice and technē, moves him to attend to the useful knowledge implicit in (...) his understanding of friendship, a knowledge by virtue of which he will be a more responsive guardian of what he values. Finally, I contend that Socrates enacts the definition of justice in question and indirectly argues for his own just art of rhetoric, which he employs in conversation with Polemarchus in his aim to be responsible to political life and to do it some good. (shrink)

In this article I interpret the conversation that takes place between Socrates and Polemarchus in Book One of the Republic according to its dramatic logic by examining the rhetorical artfulness that informs Socrates’ argumentative tactics. After first examining Polemarchus’s character as obedient spiritedness, I then turn to the argument, showing that Socrates does not undermine Polemarchus’s original opinion but, rather, by making legitimate use of the analogy between justice and technē, moves him to attend to the useful knowledge implicit in (...) his understanding of friendship, a knowledge by virtue of which he will be a more responsive guardian of what he values. Finally, I contend that Socrates enacts the definition of justice in question and indirectly argues for his own just art of rhetoric, which he employs in conversation with Polemarchus in his aim to be responsible to political life and to do it some good. (shrink)

In An Essay in Aid of a Grammar of Assent, John Henry Newman articulates his fundamental philosophical orientation by giving priority to real apprehension over notional apprehension. He distinguishes between the two by saying that notional apprehension hasto do with things internal to the mind and admits of exactness and clarity whereas real apprehension has to do with things external to the mind and does not admit of the same degree of clarity and exactness. I argue that the connection between (...) “inside the mind” and “clarity and exactness” lies in the constructive activity underlying notional thinking. Real apprehension, on the other hand, involves a given apprehension of unity, mainly, the concrete unity of intelligent life, which includes but cannot be reduced to the constructive activity of notional thinking. Thus, I argue, Newman’s realism undercuts any form of modern transcendentalism and evinces a form of classical human realism. (shrink)

The use of evidence in medicine is something we should continuously seek to improve. This book seeks to develop our understanding of evidence of mechanism in evaluating evidence in medicine, public health, and social care; and also offers tools to help implement improved assessment of evidence of mechanism in practice. In this way, the book offers a bridge between more theoretical and conceptual insights and worries about evidence of mechanism and practical means to fit the results into evidence assessment procedures.

The viewpoint that consciousness, including feeling, could be fully expressed by a computational device is known as strong artificial intelligence or strong AI. Here I offer a defense of strong AI based on machine-state functionalism at the quantum level, or quantum-state functionalism. I consider arguments against strong AI, then summarize some counterarguments I find compelling, including Torkel Franzén’s work which challenges Roger Penrose’s claim, based on Gödel incompleteness, that mathematicians have nonalgorithmic levels of “certainty.” Some consequences of strong AI are (...) then considered. A resolution is offered of some problems including John Searle’s Chinese Room problem and the problem of consciousness propagation under isomorphism. (shrink)

Strong arguments are presented by Hargrave suggesting that the crystallization of visual rhodopsin for high resolution analysis by X-ray crystallography or electron microscopy is feasible. However, the effort needed to achieve this goal will most likely exceed the resources of a single laboratory and a concerted approach to the research is necessary.

Abraham’s Luggage: A Social Life of Things in the Medieval Indian Ocean World By LambournElizabeth A., xvi + 301 pp. Price HB £75.00. EAN 978–1107173880.

text as original form and reprinted in 2020.

The author reviews the literature in professional education that cites Ernest Becker’s work from the 1960s-70s. Some of Becker’s main ideas from his own writing on education are also reviewed. The purpose here is to establish a sketch, not a full-study, of the importance of Becker’s educational legacy and begin some critique of the biases of professional educators in regard to utilizing Becker’s work. This critical reflectivity is an appropriate model of Becker’s own integrative approach to knowledge and learning. The (...) aim is to ensure that future applications may be cautious to certain reductive tendencies and offer more diverse perspectives that are truer to Becker’s oeuvre and core ideas about human behavior and societies in general, and education specifically. The author concludes that the future of Education, formal and informal, would do well to take a long serious look at Becker’s work, especially as the world’s children, youths and adults are is becoming more and more vulnerable to frightening conditions, with cascading collapse of systems, including extinctions of all kinds already well underway in an era of global threats nearing extremes. Becker’s oeuvre is both realistic and idealistic, offering Education a way to radically improve to help make for a better world. (shrink)

The author, with over three decades of focused research on fear and fearlessness and 45 years as an emancipatory educator, argues that philosophy and philosophy of education have missed several great opportunities to help bring about theoretical and meta-perspectival clarity, wisdom and compassion, and practical ways to the sphere of fear management/education (FME) throughout history. FME is not simple, nor a luxury, it is complex. It's foundational to good curriculum but it requires careful philosophical critique. This book embarks on a (...) unique transdisciplinary understanding of The Fear Problematique and how it can be integrated as a pivotal contextual reference for assessing the 'best' way to go in Education today and tomorrow. Educational philosophy is examined and shown to have largely 'missed the boat' in terms of responding critically and ethically to the insidious demand of having to truly educate ourselves when we are so scared stiff. Such a state of growing chronic fear, of morphing types of fear, and a culture of fear, ought to be central in shaping a philosophy of fear(ism) for education. The book challenges all leaders, but especially philosophers and educators, to upgrade their own fear imaginary and fear education for the 21st century, a century of terror likely to grow in the cascading global crises. (shrink)

Anselm’s ontological argument for the existence of God is examined. It is concluded that Anselm errs in assuming the greatest "thing" must be a sentient being. The existence of God, then, is not established by Anselm’s argument, and is concluded to be unlikely for other reasons as well, one being that a perfected sentient being would be a logical impossibility. An afterlife and personal immortality are not precluded however; these goals could be reached by future scientific means. For now cryonics (...) is advocated as a means to reach a more advanced future when death may be physically overcome. (shrink)

Uteroferrin, a purple‐colored, iron‐containing acid phosphatase, with many of the properties of a lysosomal hydrolase, transports iron from the mother to the conceptus in pregnant pigs. Uteroferrin, however, is but one member of what may be a broad class of iron‐containing phosphatases with unusual spectral properties which result from a novel type of di‐iron active site. The biological function of uteroferrin is unknown. We argue here that the in vivo function of uteroferrin, despite its undoubted ability to act as a (...) potent acid phosphatase, is that of a transplacental iron transporter. (shrink)